(Now there’s a first; I’ve always mandated the possessive form, “Down’s Syndrome”. The two forms sound the same, but sure look different. I finally decided that they don’t mean different, albeit the old way was probably slightly more grammatically correct. Whatever. But I digress.)

I predict the first cure(s) will be for early intervention in the very young, preventing developmental delays. In utero cures will limit physiologic defects like heart holes and appearing different.

Later cures will be “retroactive” at the cellular level for older persons with Down’s; however, old ingrained developmental delays and physiologic differences, e.g. short stature, will resist change for several more decades.

These developments will be here within a couple of decades. Ryan will be about my age by then, so he will not be a prime beneficiary. Sophie will still be sufficiently young as to have potential gain.

Bless you, Amy, for thinking and writing about these kinds of things. You have what it takes to verbalize thoughts that some of us didn’t realize we were thinking even in our subconscious minds.

Your GIAPH readers are a family, and we love you all very much.